Ausgewählte Publikationen des LIMES-Instituts

Eine Gesamtübersicht über die Publikationen der vergangenen Jahre finden Sie in unserem Broschüren-Downloadbereich.

2016

Batoulis H, Schmidt TH, Weber P, Schloetel JG, Kandt C, Lang T. Concentration Dependent Ion-Protein Interaction Patterns Underlying Protein Oligomerization Behaviours. Sci Rep. 2016 Apr 7;6:24131. 

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL. Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection. Nat Immunol. 2016 May;17(5):593-603. 

Brandstätter O, Schanz O, Vorac J, König J, Mori T,  Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser Ch, Takeyama H, Weighardt H, Förster I. Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor. Sci Rep. 2016 May 17;6:26091.

Gaebler A, Penno A, Kuerschner L, Thiele C. A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins. J Lipid Res. 2016 Oct;57(10):1934-1947. PubMed PMID: 27565170; PubMed Central PMCID: PMC5036357.

Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, Degen J, Dörmann P, Hoch M. Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. J Biol Chem. 2016 Mar 25;291(13):6989-7003. 

Hückesfeld S, Peters M, Pankratz MJ. Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain. Nat Commun. 2016 Sep 13;7:12796. doi: 10.1038/ncomms12796. PubMed PMID: 27619503; PubMed Central PMCID: PMC5027282.

Kreer C, Kuepper JM, Zehner M, Quast T, Kolanus W, Schumak B, Burgdorf S. N-glycosylation converts non-glycoproteins into mannose receptor ligands and reveals antigen-specific T cell responses in vivo. Oncotarget. 2016 Dec 28. doi: 10.18632/oncotarget.14314. [Epub ahead of print] PubMed PMID: 28036287.

Pfeiffer F, Mayer G. Selection and Biosensor Application of Aptamers for Small Molecules. Front Chem. 2016 Jun 15;4:25. 

Schlegel P, Texada MJ, Miroschnikow A, Schoofs A, Hückesfeld S, Peters M, Schneider-Mizell CM, Lacin H, Li F, Fetter RD, Truman JW, Cardona A, Pankratz MJ. Synaptic transmission parallels neuromodulation in a central food-intake circuit. Elife. 2016 Nov 15;5. pii: e16799. doi: 10.7554/eLife.16799. PubMed PMID: 27845623; PubMed Central PMCID: PMC5182061.

Schoofs A, Pankratz MJ. Neuroscience: Hunger Pangs in the Fly Brain. Curr Biol. 2016 Aug 8;26(15):R701-3. 

Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn AM, Quast T, Koch K, Nehring M, König J, Zweynert A, Harms FL, Steiner N, Limmer A, Förster I, Berberich-Siebelt F, Knolle PA, Wohlleber D, Kolanus W, Beyer M, Schultze JL, Burgdorf S. Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10649-54. doi: 10.1073/pnas.1605885113. PubMed PMID: 27601670; PubMed Central PMCID: PMC5035904.

Schultze JL, Beyer M. Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way. Immunity. 2016 Jan 19;44(1):18-20. 

Weigandt J, Chung CL, Jester SS, Famulok M. Daisy Chain Rotaxanes Made from Interlocked DNA Nanostructures. Angew Chem Int Ed Engl. 2016 Apr 25;55(18):5512-6.

2015

Destainville N, Schmidt TH, Lang T. Where Biology Meets Physics-A Converging View on Membrane Microdomain Dynamics. Curr Top Membr. 2016;77:27-65. doi: 10.1016/bs.ctm.2015.10.004. Epub 2015 Nov 27.

Kath-Schorr S, Cycloadditions for studying nucleic acids. Topics in Current Chemistry, 2015, 374, 1-27.

Lennarz S, Alich TC, Kelly T, Blind M, Beck H, Mayer G. Selective aptamer-based control of intraneuronal signaling. Angew Chem Int Ed Engl. 2015 Apr 27;54(18):5369-73. doi: 10.1002/anie.201409597. Epub 2015 Mar 5. PubMed PMID: 25754968.

Matzner D, Mayer G. (Dis)similar Analogues of Riboswitch Metabolites as Antibacterial Lead Compounds. J Med Chem. 2015 Apr 23;58(8):3275-86.

Mitschka S, Ulas T, Goller T, Schneider K, Egert A, Mertens J, Brüstle O, Schorle H, Beyer M, Klee K, Xue J, Günther P, Bassler K, Schultze JL, Kolanus W. Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71. Sci Rep. 2015 Jun 9;5:11126.

Richard M, Hoch M. Drosophila eye size is determined by Innexin 2-dependent Decapentaplegic signalling. Dev Biol. 2015 Dec 1;408(1):26-40. 

Schultze JL. Teaching 'big data' analysis to young immunologists. Nat Immunol. 2015 Sep;16(9):902-5. 

Tolle F, Brändle GM, Matzner D, Mayer G. A Versatile Approach Towards Nucleobase-Modified Aptamers. Angew Chem Int Ed Engl. 2015 Sep 7;54(37):10971-4. 

Zehner M, Marschall AL, Bos E, Schloetel JG, Kreer C, Fehrenschild D, Limmer A, Ossendorp F, Lang T, Koster AJ, Dübel S, Burgdorf S. The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells. Immunity. 2015 May 19;42(5):850-63.

2014

Mass E, Wachten D, Aschenbrenner AC, Voelzmann A and Hoch M. (2014). Murine Creld1 Controls Cardiac Development through Activation of Calcineurin/NFATc1 Signaling. Developmental cell, 28(6), 711-726.

Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, Hariharasudan G, Nino-Castro A, Mallmann M, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T and Schultze JL. (2014). Transcriptome-based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation. Immunity, Feb 20;40(2):274-88.

Sommer D, Peters A, Wirtz T, Mai M, Ackermann J, Thabet Y, Schmidt J, Weighardt H, Wunderlich FT, Degen J, Schultze JL and Beyer M. (2014). Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nature communications,  Jan 13;5:3045. doi: 10.1038/ncomms4045.

2013

De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schilberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams B, Knolle PA, Kneiling M, Rocken M, Lutjohann D, Wright SD, Schultze JL and Latz E. (2013). High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via transcriptional regulator ATF3. Nature Immunology, 2014 Feb;15(2):152-60. Epub 2013 Dec 8.

Li T and Famulok M. (2013). I-motif-programmed functionalization of DNA nanocircles. Journal of the American Chemical Society, 135(4), 1593-1599.

2012

McInnes N, Sadlon TJ, Brown CY, Pederson S, Beyer M, Schultze JL, McColl S, Goodall GJ and Barry SC. (2012). FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells. Oncogene, 31(8), 1045-1054.

Lohmann F, Ackermann D and Famulok M. (2012). Reversible light switch for macrocycle mobility in a DNA rotaxane. Journal of the American Chemical Society, 134(29), 11884-11887.

Li T, Ackermann D, Hall AM and Famulok M. (2012). Input-dependent induction of oligonucleotide structural motifs for performing molecular logic. Journal of the American Chemical Society, 134(7), 3508-3516.

Li J, Malaby AW, Famulok M, Sabe H, Lambright DG and Hsu VW. (2012). Grp1 plays a key role in linking insulin signaling to glut4 recycling. Developmental cell, 22(6), 1286-1298.

Khodosevich K, Zuccotti A, Kreuzberg MM, Le Magueresse C, Frank M, Willecke K and Monyer H. (2012). Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone. Proceedings of the National Academy of Sciences of the United States of America, 109(49), 20107-20112.

Jennemann R, Rabionet M, Gorgas K, Epstein S, Dalpke A, Rothermel U, Bayerle A, van der Hoeven F, Imgrund S, Kirsch J, Nickel W, Willecke K, Riezman H, Grone HJ and Sandhoff R. (2012). Loss of ceramide synthase 3 causes lethal skin barrier disruption. Human molecular genetics, 21(3), 586-608.

Contreras FX, Ernst AM, Haberkant P, Bjorkholm P, Lindahl E, Gonen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F and Brugger B. (2012). Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature, 481(7382), 525-529.

2011

Zehner M, Chasan AI, Schuette V, Embgenbroich M, Quast T, Kolanus W and Burgdorf S. (2011). Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation. Proceedings of the National Academy of Sciences of the United States of America, 108(24), 9933-9938.

Tress O, Maglione M, Zlomuzica A, May D, Dicke N, Degen J, Dere E, Kettenmann H, Hartmann D and Willecke K. (2011). Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans. PLoS genetics, 7(7), e1002146.

Schutz M, Auth T, Gehrt A, Bosen F, Korber I, Strenzke N, Moser T and Willecke K. (2011). The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome. Human molecular genetics, 20(1), 28-39.

Quast T, Eppler F, Semmling V, Schild C, Homsi Y, Levy S, Lang T, Kurts C and Kolanus W. (2011). CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration. Blood, 118(7), 1818-1827.

Hagen N, Hans M, Hartmann D, Swandulla D and van Echten-Deckert G. (2011). Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. Cell death and differentiation, 18(8), 1356-1365.

Bill A, Blockus H, Stumpfe D, Bajorath J, Schmitz A and Famulok M. (2011). A homogeneous fluorescence resonance energy transfer system for monitoring the activation of a protein switch in real time. Journal of the American Chemical Society, 133(21), 8372-8379.

Beyer M, Thabet Y, Muller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schonfeld EA, Bottcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL and Schultze JL. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nature immunology, 12(9), 898-907.

2010

Bill A, Schmitz A, Albertoni B, Song JN, Heukamp LC, Walrafen D, Thorwirth F, Verveer PJ, Zimmer S, Meffert L, Schreiber A, Chatterjee S, Thomas RK, Ullrich RT, Lang T and Famulok M. (2010). Cytohesins are cytoplasmic ErbB receptor activators. Cell, 143(2), 201-211.

Stutte S, Quast T, Gerbitzki N, Savinko T, Novak N, Reifenberger J, Homey B, Kolanus W, Alenius H and Förster I. (2010). Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells. Proceedings of the National Academy of Sciences of the United States of America, 107(19), 8736-8741.

Mayer G, Ahmed MS, Dolf A, Endl E, Knolle PA and Famulok M. (2010). Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures. Nature protocols, 5(12), 1993-2004.

Burgdorf S, Schuette V, Semmling V, Hochheiser K, Lukacs-Kornek V, Knolle PA and Kurts C. (2010). Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proceedings of the National Academy of Sciences of the United States of America, 107(13), E48-49; author reply E50-41.

Becker T, Loch G, Beyer M, Zinke I, Aschenbrenner AC, Carrera P, Inhester T, Schultze JL and Hoch M. (2010). FOXO-dependent regulation of innate immune homeostasis. Nature, 463(7279), 369-373.

Ackermann D, Schmidt TL, Hannam JS, Purohit CS, Heckel A and Famulok M. (2010). A double-stranded DNA rotaxane. Nature nanotechnology, 5(6), 436-442.

2009

Quast T, Tappertzhofen B, Schild C, Grell J, Czeloth N, Forster R, Alon R, Fraemohs L, Dreck K, Weber C, Lammermann T, Sixt M and Kolanus W. (2009). Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Blood, 113(23), 5801-5810.

Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C and Knolle PA. (2009). The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. The Journal of experimental medicine, 206(10), 2079-2089.

Dobrowolski R, Hertig G, Lechner H, Worsdorfer P, Wulf V, Dicke N, Eckert D, Bauer R, Schorle H and Willecke K. (2009). Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Human molecular genetics, 18(15), 2899-2911.

Beyer M, Karbach J, Mallmann MR, Zander T, Eggle D, Classen S, Debey-Pascher S, Famulok M, Jager E and Schultze JL. (2009). Cancer vaccine enhanced, non-tumor-reactive CD8(+) T cells exhibit a distinct molecular program associated with "division arrest anergy". Cancer research, 69(10), 4346-4354.

Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, Eckardt F, Sandhoff K and Hoch M. (2009). Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. The EMBO journal, 28(23), 3706-3716.

2008

Loer B, Bauer R, Bornheim R, Grell J, Kremmer E, Kolanus W and Hoch M. (2008). The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link. Nature cell biology, 10(4), 422-428.

Hafner M, Vianini E, Albertoni B, Marchetti L, Grune I, Gloeckner C and Famulok M. (2008). Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization. Nature protocols, 3(4), 579-587.

Burgdorf S, Scholz C, Kautz A, Tampe R and Kurts C. (2008). Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nature immunology, 9(5), 558-566.

Buch S, Melcher C, Bauer M, Katzenberger J and Pankratz MJ. (2008). Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling. Cell metabolism, 7(4), 321-332.

2007

Roell W, Lewalter T, Sasse P, Tallini YN, Choi BR, Breitbach M, Doran R, Becher UM, Hwang SM, Bostani T, von Maltzahn J, Hofmann A, Reining S, Eiberger B, Gabris B, Pfeifer A, Welz A, Willecke K, Salama G, Schrickel JW, Kotlikoff MI and Fleischmann BK. (2007). Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature, 450(7171), 819-824.

Gareus R, Huth M, Breiden B, Nenci A, Rosch N, Haase I, Bloch W, Sandhoff K and Pasparakis M. (2007). Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nature cell biology, 9(4), 461-469.

Burgdorf S, Kautz A, Bohnert V, Knolle PA and Kurts C. (2007). Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science, 316(5824), 612-616.

Behr M, Wingen C, Wolf C, Schuh R and Hoch M. (2007). Wurst is essential for airway clearance and respiratory-tube size control. Nature cell biology, 9(7), 847-853.

2006

Hafner M, Schmitz A, Grune I, Srivatsan SG, Paul B, Kolanus W, Quast T, Kremmer E, Bauer I and Famulok M. (2006). Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Nature, 444(7121), 941-944.

Fuss B, Becker T, Zinke I and Hoch M. (2006). The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature, 444(7121), 945-948.