How do the organs of our body develop and how are their physiological functions controlled? Are energy homeostasis, innate immunity and ageing linked to each other? Do fasting or overeating affect our immune system? What role does the gut microbiome play? To address these and other questions, we utilize the genetic model systems fruit fly, mouse and zebrafish in combination with biochemistry and molecular cell biology.
Our overall goal is to understand how metabolism influences growth and how energy homeostasis impacts on the activity of organ systems such as the immune system, in health and disease. We have also begun to study how nutrition regulates cell and organ physiology, how it modulates genetic diseases (such as lipid storage diseases or neurodegeneration) and how it controls healthy ageing.
Our research group consists of an international team of enthusiastic scientists representing 7 countries worldwide. We put particular emphasis on creativity, diligence and a strong team spirit. The tools and model organisms we employ to address our research questions provide an outstanding opportunity for education and research development at all career levels. Our research is funded by the German Research Foundation (SFBs 645, 704, TRR 83). Prof. Hoch was the speaker of the SFB 645 and is a member of the steering committees of the SFB 704 and the Bonn Excellence Cluster ImmunoSensation. We are actively involved in cooperation and student exchange with Waseda University and TUAT in Tokyo, Japan.