Only a small percentage of the mammalian genome encodes proteins but most of it is transcribed into RNA. The remaining, non-coding RNA molecules play major roles in transcriptional and translational regulation, mRNA processing, transport and localization, posttranslational modification and protein degradation and translocation. In all cases, their capability to fold into complex three-dimensional structures determines their function.
Our research focusses on the investigation of functional RNA – the role of non-coding RNAs, ribozymes, RNA-RNA interactions and the visualization of functional RNA molecules.
Our projects combine organic synthesis to obtain complex unnatural nucleotide building blocks, as well as chemical biology approaches to answer biological questions of specific RNA folding and function.