Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors generate pre-macrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day (E)9.5 in a chemokine-receptor dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in early macrophages. This process appears essential for macrophage specification and maintenance, as inactivation of Id3 impairs the development of liver macrophages and results in selective Kupffer cell deficiency in adults. We propose that macrophage differentiation is an integral part of organogenesis as colonization of organ anlagen by pMacs is followed by their specification into tissue macrophages, hereby generating the macrophage diversity observed in postnatal tissues.
Unit 1
Unit 1: Genetik, Entwicklungsbiologie & Molekulare Physiologie
- Margret Bülow: Zellstoffwechsel von Neuronen
- Michael Hoch/Reinhard Bauer: Entwicklungsgenetik & Molekulare Physiologie
- Elvira Mass: Entwicklungsbiologie des Immunsystems
- Michael Pankratz: Molekulare Hirnphysiologie & Verhaltensforschung
- Dietmar Schmucker: Entwicklung neuronaler Verschaltungen
- Peter Soba: Neuronale Musterbildung und Konnektivität
Unit 2
Unit 2: Molekulare Immun- & Zellbiologie
- Sven Burgdorf: Zelluläre Immunologie
- Irmgard Förster: Immunologie & Umwelt
- Jan Hasenauer: Rechnergestützte Lebenswissenschaften
- Eva Kiermaier: Immun- und Tumorbiologie
- Waldemar Kolanus: Molekulare Immunologie und Zellbiologie
- Mihai Netea: Immunologie und Metabolismus
- Joachim Schultze: Genomik & Immunregulation
- Ivonne Vazquez Armendariz: Organoide Biologie
- Andreas Schlitzer: Quantitative Systembiologie
Unit 3
Unit 4
Ehemalige Gruppen