Collaborative Research Center SFB 645

"Regulation and manipulation of information flow
within dynamic protein and lipid environments"

Members & Projects

Project Section A: Biological and chemical modulation of membrane molecule function and dynamics

No.	Title	Research area	PI, Institute
A1	Membrane-proximal signaling events in migrating immune cells	Cell biology, immunology	Prof. Dr. W. Kolanus, Dr. Thomas Quast, LIMES-Institute, Molecular Immunology, Bonn
A3	Functional analysis of cytohesin-mediated membrane receptor tyrosine kinase signaling	Chemical Biology, Molecular Biomedicine, Biochemistry	Prof. M. Famulok, LIMES Insitute Chemical Biology & Medicinal Chemistry, Bonn
A7	Sphingolipid metabolism and autophagy in Alzheimer's disease	Lipid Metabolism, Neurodegeneration	Prof. Jochen Walter, Department of Neurology, University Hospital, Bonn
A9	Mechanisms of non-genomic progesterone signaling in human sperm	Biophysics, Physiology	Prof. Ulrich Benjamin Kaupp, Dr. Timo Strünker Center of European Studies and Research (caesar), Bonn
A10	Molecular mechanisms, dynamics and nano-anatomical aspects of membrane protein clustering	Membrane molecule dynamics, membrane biochemistry, cell biology	Prof. Thorsten Lang, LIMES Institute, Membrane Biochemistry, Bonn

Project Section B: Genetic and biochemical manipulation of the lipid metabolism for the analysis of membrane protein function

No.	Title	Research area	PI, Institute
B1	Role of ceramide synthases in linking cellular lipid synthesis with body fat metabolism	Lipid Metabolism	PD. Dr. Reinhard Bauer, Prof. Dr. Michael Hoch LIMES-Institute, Development & Genetics, Bonn
B2	Cell biological characterization and function of different ceramides including sphingolipid derivatives in mice	Molecular genetics and biological functions of lipids	Sen. Prof. em. Klaus Willecke, LIMES Institute, Bonn
B3	Functions and mechanisms of endolysosomal enzymes and lipid binding proteins (LLBPs)	Biochemistry, Biophysics, Lipid metabolism	Sen. Prof. em. Konrad Sandhoff, LIMES-Institute, University of Bonn
B5	Functional consequences of altered sphingolipid metabolism in myelinating cells	Biochemistry	PD Dr. Matthias Eckhardt, Institute of Biochemistry and Molecular Biology (IBMB), University of Bonn
B7	Endocannabinoids: Metabolites of phospholipids as modulators of brain to bone signaling	Lipid signalling, Depression, Growth regulation	Prof. Andreas Zimmer, Institute of Molecular Psychiatry, University of Bonn Prof. Itai Bab, Bone Laboratory, Jerusalem
B9	Physiological and pathological role of GBA2 in controlling cellular dynamics	Lipid Metabolism and signaling	Dagmar Wachten caesar, Bonn
B10	Physiological Function of the lipid droplet AUP1	Lipid Metabolism	Prof. Christoph Thiele, LIMES-Institute, University of Bonn
B11	Regulation of innate immune activation by high density lipoproteins	Lipiid Metabolism	Prof. Eicke Latz, Institute of Innate Immunity, University of Bonn

Project Section C: Membrane Trafficking

No.	Title	Research area	PI, Institute
C1	Role of mannose receptor-mediated endocytosis in antigen cross-presentation	Immunology, Cell Biology	Prof. Sven Burgdorf, LIMES-Institute, University of Bonn Prof. Christian Kurts, Institute of Innate Immunity, University of Bonn
C2	Cell-free analysis of phagosome biogenesis in macrophages	Cell Biology of Infection	Prof. A. Haas, Institute for Cell Biology, Universityof Bonn
C5	Role of Wurst/Dnajc22 proteins in endocytosis at barrier tissues	Endocytosis	Dr. Matthias Behr Prof. Dr. Michael Hoch LIMES Institute, University of Bonn
C6	Regulation of membrane dynamics during chaperone-assisted selective autophagy	Cell Biology	Prof. Jörg Höhfeld Institute for Cell Biology, University of Bonn
Z2	Central services		Prof. Dr. Michael Hoch LIMES Institute University of Bonn
Z4	Mass spectrometry service project	Analysis of proteins and lipids by mass spectrometry	Prof. Volkmar Gieselmann, Institute of Biochemistry and Molecular Biology, University of Bonn
	Mass spectrometry service project	Quantification of lipids by mass spectrometry	Prof. Peter Dörmann, Institute of Molecular Physiology and Biotechnology of Plants (IMBIO), Bonn
	Lipid Metabolism	Quantitative analysis of lipid metabolism	Prof. Christoph Thiele, LIMES Institute, University of Bonn
Z5	Transcriptional regulation of proteins involved in membrane biology and lipid metabolism	Transcriptional regulation, genomics, next generation sequencing microarray	Prof. Joachim L. Schultze LIMES Institute, University of Bonn