Sonderforschungsbereich SFB 645

"Regulation und Manipulation von biologischer Informationsübertragung in dynamischen Protein-
und Lipidumgebungen"

Mitglieder & Projekte

Project Section A: Biological and chemical modulation of membrane molecule function and dynamics



Research area

PI, Institute


Membrane-proximal signaling events in migrating immune cellsCell biology, immunologyProf. Dr. W. Kolanus,
Dr. Thomas Quast,
LIMES-Institute, Molecular Immunology, Bonn


Functional analysis of cytohesin-mediated membrane receptor tyrosine kinase signalingChemical Biology, Molecular Biomedicine, BiochemistryProf. M. Famulok,
LIMES Insitute
Chemical Biology & Medicinal Chemistry, Bonn


Sphingolipid metabolism and autophagy in Alzheimer's diseaseLipid Metabolism, NeurodegenerationProf. Jochen Walter,
Department of Neurology, University Hospital, Bonn


Mechanisms of non-genomic progesterone signaling in human spermBiophysics,
Prof. Ulrich Benjamin Kaupp,
Dr. Timo Strünker
Center of European Studies and Research
(caesar), Bonn


Molecular mechanisms, dynamics and nano-anatomical aspects of membrane protein clusteringMembrane molecule dynamics, membrane biochemistry, cell biologyProf. Thorsten Lang, LIMES Institute, Membrane Biochemistry, Bonn

Project Section B: Genetic and biochemical manipulation of the lipid metabolism for the analysis of membrane protein function



Research area

PI, Institute


Role of ceramide synthases in linking cellular
lipid synthesis with body fat metabolism
Lipid MetabolismPD. Dr. Reinhard Bauer,
Prof. Dr. Michael Hoch
LIMES-Institute, Development &
Genetics, Bonn


Cell biological characterization and function of different ceramides including sphingolipid
derivatives in mice
Molecular genetics and biological functions of lipidsSen. Prof. em. Klaus Willecke,
LIMES Institute, Bonn


Functions and mechanisms of endolysosomal enzymes and lipid binding proteins (LLBPs)Biochemistry, Biophysics, Lipid metabolismSen. Prof. em. Konrad Sandhoff,
LIMES-Institute, University of Bonn


Functional consequences of altered sphingolipid metabolism in myelinating cellsBiochemistryPD Dr. Matthias Eckhardt,
Institute of Biochemistry and Molecular Biology (IBMB), University of Bonn


Endocannabinoids: Metabolites of
phospholipids as modulators of
brain to bone signaling
Lipid signalling, Depression, Growth regulationProf. Andreas Zimmer,
Institute of Molecular Psychiatry, University of Bonn
Prof. Itai Bab, Bone Laboratory, Jerusalem


Physiological and pathological role of GBA2 in controlling cellular dynamicsLipid Metabolism and signalingDagmar Wachten
caesar, Bonn


Physiological Function of the lipid droplet AUP1Lipid MetabolismProf. Christoph Thiele,
LIMES-Institute, University of Bonn


Regulation of innate immune activation by high density lipoproteinsLipiid Metabolism

Prof. Eicke Latz,
Institute of Innate Immunity, University of Bonn

Project Section C: Membrane Trafficking

Research area
PI, Institute
Role of mannose receptor-mediated endocytosis in antigen cross-presentation Immunology, Cell Biology

Prof. Sven Burgdorf,
LIMES-Institute, University of Bonn
Prof. Christian Kurts,
Institute of Innate Immunity, University of Bonn

Cell-free analysis of phagosome
biogenesis in macrophages
Cell Biology of InfectionProf. A. Haas,
Institute for Cell Biology, Universityof Bonn
Role of Wurst/Dnajc22 proteins in endocytosis at barrier tissuesEndocytosisDr. Matthias Behr
Prof. Dr. Michael Hoch
LIMES Institute, University of Bonn
Regulation of membrane dynamics during chaperone-assisted selective autophagyCell BiologyProf. Jörg Höhfeld
Institute for Cell Biology, University of Bonn
Central services Prof. Dr. Michael Hoch
LIMES Institute
University of Bonn
Mass spectrometry service projectAnalysis of proteins and lipids by mass spectrometryProf. Volkmar Gieselmann,
Institute of Biochemistry and Molecular Biology, University of Bonn
Mass spectrometry service projectQuantification of lipids by mass spectrometryProf. Peter Dörmann,
Institute of Molecular Physiology and Biotechnology of Plants (IMBIO), Bonn
Lipid MetabolismQuantitative analysis of lipid metabolismProf. Christoph Thiele,
LIMES Institute, University of Bonn
Transcriptional regulation of proteins involved in membrane biology and lipid metabolismTranscriptional regulation, genomics, next generation sequencing microarrayProf. Joachim L. Schultze
LIMES Institute, University of Bonn