Publications

 

Schuette, V., Burgdorf, S. The ins-and-outs of endosomal antigens for cross-presentation. (2014) Curr Opin Immunol. DOI 10.1016/j.coi.2013.11.001

Madsen,D.H., Leonard, D., Masedunskas, A., Moyer, A., Jurgensen, H.J., Peters, D.E., Amornphimolthan, P., Selvaraj, A., Yamada, S.S., Brenner, D.A., Burgdorf, S., Engelholm, L.H., Behrendt, N., Holmbeck, K., Weigert, R., Bugge, T.H. (2013) M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway J Cell Biol, 202: 951-966.

Zehner, M. and Burgdorf, S. Regulation of antigen transport into the cytosol for cross-presentation by ubiquitination of the Mannose Receptor (2013). Mol Immunol, 55: 146-148.

Chasan AI, Beyer B, Kurts C, Burgdorf S. (2013). Isolation of a specialized, antigen-loaded early endosomal subpopulation by flow cytometry. Methods Mol Biol, 960: 379-388.

Franken, L., Kurts, C. and Burgdorf, S. (2013) Monitoring the intracellular routing of internalized antigens by immunofluorescence microscopy. Methods Mol Biol, 960: 371-377

Zehner, M., Rauen, J., Chasan, A.I., Embgenbroich, M., Camps, M.G., Kaden, S., Haas, A., Kurts, C., Endl, E., Beyer, M., Gröne, H.J., Ossendorp, F. and Burgdorf, S. (2012) Intraendosomal flow cytometry: A novel approach to analyze the protein composition of antigen-loaded endosomes. Eur J Immunol, 42: 1-4.

Everts, B., Hussaarts, l., Driessen, N.N., Meevissen, M.H.J., Schramm, G., van der Ham, A.J., van der Hoeven, B., Burgdorf, S., Mohrs, M., Pearce, E.J., Hokke, C.H., Haas, H., Smits, H.H. and Yazdanbakhsh, M. (2012) Schistosome‐derived omega‐1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. J Exp Med, 209: 1753-1767.

Ilchmann, A., Krause, M., Heilmann, M., Burgdorf, S., Vieths, S. and Toda, M. (2012) Impact of culture medium on maturation of bone marrow-derived murine dendritic cells via the aryl hydrocarbon receptor. Mol Immunol, 51(1): 42-50.

Zehner, M., Chasan, A.I., Schuette, V., Embgenbroich, M., Quast, T., Kolanus, W., Burgdorf S. (2011) Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation. Proc Natl Acad Sci USA, 108(24): 9933-9938.

Kreer C, Rauen J, Zehner M, Burgdorf S. (2011) Cross-Presentation: How to Get there - or How to Get the ER. Front Immunol, 2:87.

Singh, S.K., Streng-Ouwehand, I., Litjens, M., Kalay, H., Burgdorf, S., Saeland, E., Kurts, C., Unger, W.W., van Kooyk, Y. (2011) Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization. Eur J Immunol, 41(4): 916-925.

Schwandt T, Schumak B, Gielen GH, Jüngerkes F, Schmidbauer P, Klocke K, Staratschek-Jox A, van Rooijen N, Kraal G, Ludwig-Portugall I, Franken L, Wehner S, Kalff JC, Weber O, Kirschning C, Coch C, Kalinke U, Wenzel J, Kurts C, Zawatzky R, Holzmann B, Layland L, Schultze JL, Burgdorf S, den Haan JM, Knolle PA, Limmer A. (2011) Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J, 31(1): 201-213.

Popovic, Z.V., Wang, S., Papatriantafyllou, M., Kaya, Z., Porubsky, S., Meisner, M., Bonrouhi, M., Burgdorf, S., Young, M.R., Schaefer, L. and Gröne H.-J. (2011) The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. J Immunol, 187(12): 6217-6262.

Madsen, D.H., Ingvarsen, S., Jürgensen, H.J., Melander, M.C., Kjøller, L., Moyer, A., Honoré, C., Madsen, C.A., Garred, P., Burgdorf, S., Bugge, T.H., Behrendt, N. and Engelholm, L.H. (2011). The non-phagocytic route of collagen uptake: a distinct degradation pathway. J Biol Chem, 286(30): 26996-27010.

Burgdorf, S., Schuette, V., Semmling, V., Hochheiser, K., Lukacs-Kornek, V., Knolle, P.A. and Kurts C (2010) Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proc Natl Acad Sci USA, 107(13):E48-9.

Schurich, A., Berg, M., Stabenow, D., Böttcher, J., Kern, M., Schild, H.J., Kurts, C., Schuette, V., Burgdorf, S., Diehl, L., Limmer, A. and Knolle, P.A. (2010) Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells. J Immunol, 184(8):4107-14.

Klotz, L., Hucke, S., Thimm, D., Schultze, J., Edenhofer, F., Kurts, C., Klockgether, T., Knolle, P. and Burgdorf, S. (2009) Increased antigen cross-presentation but impaired cross-priming after activation of PPARg is mediated by up-regulation of B7H1. J Immunol, 183(1):129-136.

Klotz, L., Burgdorf, S., Dani, I., Saijo, K., Flossdorf, J., Hucke, S., Alferink, J., Novak, N., Beyer, M., Mayer, G., Langhans, B., Klockgether, T., Waisman, A., Eberl, G., Schultze, J., Famulok, M., Kolanus, W., Glass, C., Kurts C. and Knolle, P.A, (2009) The nuclear receptor PPARg selectively controls TH17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med, 206:2079-2089.

Schurich, A., Böttcher, J.P., Burgdorf, S., Penzler, P., Hegenbarth, S., Kern, M., Dolf, A., Endl, E., Schultze, J., Wiertz, E., Stabenow, D., Kurts, C. and Knolle P. (2009) Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells. Hepatology, 50(3):909-19

Ilchmann, A., Burgdorf, S., Waibler, Z., Nagai, R., Wellner, A., Yamamoto, Y., Yamamoto, H., Scheurer, S., Henle, T., Kurts, C., Kalinke, U., Vieths, S., Toda, M. (2009) Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: the role of macrophage scavenger receptor class A type I and II. J Allergy Clin Immunol, 125(1):175-83.

Burgdorf, S., Schölz, C., Kautz, A., Tampé, R. and Kurts, C. (2008) Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol, 9(5): 558-566.

Burgdorf, S. and Kurts, C. (2008) Endocytosis mechanisms and the cell biology of antigen-presentation. Curr Opin Immunol, 20(1):89-95.

Lukacs-Kornek V., Burgdorf S., Diehl L., Specht S., Kornek M., Kurts C. (2008) The Kidney-Renal Lymph Node-System Contributes to Cross-Tolerance against Innocuous Circulating Antigen. J Immunol. 180(2):706-15.

Burgdorf, S., Kautz, A., Böhnert, V., Knolle, P.A. and Kurts C. (2007). Distinct antigen uptake and intracellular routing mechanisms for CD4 or CD8 T cell activation. Science, 316(5824):612-6.

Felten, A., Leister, P., Burgdorf, S., Uhlmann, L.  and Scheidtmann, K.H. (2007). Characterization of rat BLOS2/Ceap, a putative yeast She3 homolog, as interaction partner of apoptosis antagonizing transcription factor/Che-1. Biol Chem, 388(6):569-82.

Burgdorf, S., Lukacs-Kornek, V. and Kurts, C. (2006). The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. J Immunol, 176(11):6770-6.

Burgdorf, S., Leister, P. and Scheidtmann, K.H. (2004). TSG101 interacts with AATF and enhances AR-mediated transcription by promoting its mono-ubiquitination. J Biol Chem, 279(17):17524-34.

Leister, P.*, Burgdorf, S.* and Scheidtmann, K.H. (2003). Apoptosis antagonizing transcription factor AATF is a novel coactivator of nuclear hormone receptors. Signal Transduction, 3:17-25.

* Contributed equally