Publications

2018

Doebbeler, M., Koenig, C., Krzyzak, L., Seitz, C., Wild, A., Ulas, T., Baßler, K., Kopelyanskiy, D., Butterhof, A., Kuhnt, C., Kreiser, S., Stich, L., Zinser, E., Knippertz, I., Wirtz, S., Riegel, C., Hoffmann, P., Edinger, M., Nitschke, L., Winkler, T., Schultze, J. L., Steinkasserer, A. & Lechmann, M. CD83 expression is essential for Treg cell differentiation and stability. JCI Insight 3, (2018).

Bickert, A., Kern, P., van Uelft, M., Herresthal, S., Ulas, T., Gutbrod, K., Breiden, B., Degen, J., Sandhoff, K., Schultze, J. L., Dörmann, P., Hartmann, D., Bauer, R. & Willecke, K. Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 1863, 734–749 (2018).

Vogl, T., Stratis, A., Wixler, V., Völler, T., Thurainayagam, S., Jorch, S. K., Zenker, S., Dreiling, A., Chakraborty, D., Fröhling, M., Paruzel, P., Wehmeyer, C., Hermann, S., Papantonopoulou, O., Geyer, C., Loser, K., Schäfers, M., Ludwig, S., Stoll, M., Leanderson, T., Schultze, J. L., König, S., Pap, T. & Roth, J. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation J. Clin. Invest. 128, 1852–1866 (2018).

Schultze, J. L., SYSCID consortium, Rosenstiel P.Systems Medicine in Chronic Inflammatory Diseases.. Immunity (2018).

Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze, J. L., Bäckhed F, Rosenstiel P. Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development. Genome Med. (2018).

Bickert A, Kern P, van Uelft M, Herresthal S, Ulas T, Gutbrod K, Breiden B, Degen J, Sandhoff K, Schultze, J. L., Dörmann P, Hartmann D, Bauer R, Willecke K. Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.. Biophys Acta. (2018).

Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze, J. L., König S, Pap T, Roth J.Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest (2018).

Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, Blank T, Staszewski O, Datta M, Centeno TP, Capece V, Islam MR, Kerimoglu C, Staufenbiel M, Schultze, J. L., Beyer M, Prinz M, Jucker M, Fischer A, Neher JJ.Innate immune memory in the brain shapes neurological disease hallmarks. Nature (2018).

Gulei, D., Irimie, A. I., Cojocneanu-Petric, R., Schultze, J. L. and Berindan-Neagoe, I Exosomes-Small Players, Big Sound.. Bioconjug. Chem. 29, 635–648 (2018).

Schultze, J. L. & Aschenbrenner, A. C. Systems immunology allows a new view on human dendritic cells.. Semin. Cell Dev. Biol. (2018).

Fulle, L., Steiner, N., Funke, M., Gondorf, F., Pfeiffer, F., Siegl, J., Opitz, F. V, Hassel, S. K., Erazo, A. B., Schanz, O., Stunden, H. J., Blank, M., Grober, C., Handler, K., Beyer, M., Weighardt, H., Latz, E., Schultze, J. L., Mayer, G. and Forster, I. RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity. In Vivo. Mol. Ther (2018).

Thion, M. S., Low, D., Silvin, A., Chen, J., Grisel, P., Schulte-Schrepping, J., Blecher, R., Ulas, T., Squarzoni, P., Hoeffel, G., Coulpier, F., Siopi, E., David, F. S., Scholz, C., Shihui, F., Lum, J., Amoyo, A. A., Larbi, A., Poidinger, M., Buttgereit, A., Lledo, P.-M., Greter, M., Chan, J. K. Y., Amit, I., Beyer, M., Schultze, J. L., Schlitzer, A., Pettersson, S., Ginhoux, F. Garel, S. J. Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner.. Cell 172, 500–516.e16 (2018).

Christ, A., Gunther, P., Lauterbach, M. A. R., Duewell, P., Biswas, D., Pelka, K., Scholz, C. J., Oosting, M., Haendler, K., Bassler, K., Klee, K., Schulte-Schrepping, J., Ulas, T., Moorlag, S. J. C. F. M., Kumar, V., Park, M. H., Joosten, L. A. B., Groh, L. A., Riksen, N. P., Espevik, T., Schlitzer, A., Li, Y., Fitzgerald, M. L., Netea, M. G., Schultze, J. L. and Latz, E. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.. Cell 172, 162–175.e14 (2018).

Mitroulis, I., Ruppova, K., Wang, B., Chen, L.-S., Grzybek, M., Grinenko, T., Eugster, A., Troullinaki, M., Palladini, A., Kourtzelis, I., Chatzigeorgiou, A., Schlitzer, A., Beyer, M., Joosten, L. A. B., Isermann, B., Lesche, M., Petzold, A., Simons, K., Henry, I., Dahl, A., Schultze, J. L., Wielockx, B., Zamboni, N., Mirtschink, P., Coskun, U., Hajishengallis, G., Netea, M. G. and Chavakis, T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.Cell 172, 147–161.e12 (2018).

Ulas, T., Schultze, J. L. and Beyer, M. Bioinformatic Assessment of Macrophage Activation by the Innate Immune System. Methods Mol. Biol. 1714, 19–40 (2018).

2017

Wischhof, L., Maida, S., Piazzesi, A., Gioran, A., Barragan Sanz, K., Irsen, S., Beyer, M., Schultze, J. L., Dyer, M. J., Salomoni, P., Ehninger, D., Nicotera, P. and Bano, D. The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function. Sci. Rep. 7, 17055 (2017).

Sander, J., Schmidt, S. V, Cirovic, B., McGovern, N., Papantonopoulou, O., Hardt, A.-L., Aschenbrenner, A. C., Kreer, C., Quast, T., Xu, A. M., Schmidleithner, L. M., Theis, H., Thi Huong, L. Do, Sumatoh, H. R. Bin, Lauterbach, M. A. R., Schulte-Schrepping, J., Gunther, P., Xue, J., Bassler, K., Ulas, T., Klee, K., Katzmarski, N., Herresthal, S., Krebs, W., Martin, B., Latz, E., Handler, K., Kraut, M., Kolanus, W., Beyer, M., Falk, C. S., Wiegmann, B., Burgdorf, S., Melosh, N. A., Newell, E. W., Ginhoux, F., Schlitzer, A. and Schultze, J. L.Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity 47, 1051–1066.e12 (2017).

Hosel, M., Quasdorff, M., Ringelhan, M., Kashkar, H., Debey-Pascher, S., Sprinzl, M. F., Bockmann, J.-H., Arzberger, S., Webb, D., von Olshausen, G., Weber, A., Schultze, J. L., Buning, H., Heikenwalder, M. and Protzer, U. Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication. Cell. Mol. Gastroenterol. Hepatol. 4, 339–363 (2017).

Camell, C. D., Sander, J., Spadaro, O., Lee, A., Nguyen, K. Y., Wing, A., Goldberg, E. L., Youm, Y.-H., Brown, C. W., Elsworth, J., Rodeheffer, M. S., Schultze, J. L. and Dixit, V. D. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature 550, 119–123 (2017).

Bilkei-Gorzo, A., Albayram, O., Draffehn, A., Michel, K., Piyanova, A., Oppenheimer, H., Dvir-Ginzberg, M., Racz, I., Ulas, T., Imbeault, S., Bab, I., Schultze, J. L. and Zimmer, A. A chronic low dose of Delta(9)-tetrahydrocannabinol (THC) restores cognitive function in old mice. Nat. Med. 23, 782–787 (2017).

See, P., Dutertre, C.-A., Chen, J., Gunther, P., McGovern, N., Irac, S. E., Gunawan, M., Beyer, M., Handler, K., Duan, K., Sumatoh, H. R. Bin, Ruffin, N., Jouve, M., Gea-Mallorqui, E., Hennekam, R. C. M., Lim, T., Yip, C. C., Wen, M., Malleret, B., Low, I., Shadan, N. B., Fen, C. F. S., Tay, A., Lum, J., Zolezzi, F., Larbi, A., Poidinger, M., Chan, J. K. Y., Chen, Q., Renia, L., Haniffa, M., Benaroch, P., Schlitzer, A., Schultze, J. L., Newell, E. W. and Ginhoux, F. Mapping the human DC lineage through the integration of high-dimensional techniques. Science 356, (2017).

Aschenbrenner, A. C., Bassler, K., Brondolin, M., Bonaguro, L., Carrera, P., Klee, K., Ulas, T., Schultze, J. L. and Hoch, M. A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a. Sci. Rep. 7, 4056 (2017).

Ulas, T., Pirr, S., Fehlhaber, B., Bickes, M. S., Loof, T. G., Vogl, T., Mellinger, L., Heinemann, A. S., Burgmann, J., Schoning, J., Schreek, S., Pfeifer, S., Reuner, F., Vollger, L., Stanulla, M., von Kockritz-Blickwede, M., Glander, S., Barczyk-Kahlert, K., von Kaisenberg, C. S., Friesenhagen, J., Fischer-Riepe, L., Zenker, S., Schultze, J. L., Roth, J. and Viemann, D.S100-alarmin-induced innate immune programming protects newborn infants from sepsis. Nat. Immunol. 18, 622–632 (2017).

Aschenbrenner, A. C. and Schultze, J. L.New ‘programmers’ in tissue macrophage activation. Pflugers Arch. 469, 375–383 (2017).

Sander, J., Schultze, J. L. and Yosef, N. ImpulseDE: detection of differentially expressed genes in time series data using impulse models. Bioinformatics 33, 757–759 (2017).

Schlitzer, A. and Schultze, J. L.Tissue-resident macrophages - how to humanize our knowledge. Immunol. Cell Biol. 95, 173–177 (2017).

Schultze, J. L.Chromatin Remodeling in Monocyte and Macrophage Activation. Adv. Protein Chem. Struct. Biol. 106, 1–15 (2017).

Heine, A., Held, S. A. E., Schulte-Schrepping, J., Wolff, J. F. A., Klee, K., Ulas, T., Schmacke, N. A., Daecke, S. N., Riethausen, K., Schultze, J. L. and Brossart, P. Generation and functional characterization of MDSC-like cells. Oncoimmunology 6, e1295203 (2017).

2016

Heidkamp, G. F., Sander, J., Lehmann, C. H. K., Heger, L., Eissing, N., Baranska, A., Luhr, J. J., Hoffmann, A., Reimer, K. C., Lux, A., Soder, S., Hartmann, A., Zenk, J., Ulas, T., McGovern, N., Alexiou, C., Spriewald, B., Mackensen, A., Schuler, G., Schauf, B., Forster, A., Repp, R., Fasching, P. A., Purbojo, A., Cesnjevar, R., Ullrich, E., Ginhoux, F., Schlitzer, A., Nimmerjahn, F., Schultze, J. L. and Dudziak, D. Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment. Sci. Immunol. 1, (2016).

Stunnenberg, H. G. and Hirst, M. The International Human Epigenome Consortium: The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell 167, 1145–1149 (2016).

Durek, P., Nordstrom, K., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., Bassler, K., Ulas, T., Schmidt, F., Xiong, J., Glazar, P., Klironomos, F., Sinha, A., Kinkley, S., Yang, X., Arrigoni, L., Amirabad, A. D., Ardakani, F. B., Feuerbach, L., Gorka, O., Ebert, P., Muller, F., Li, N., Frischbutter, S., Schlickeiser, S., Cendon, C., Frohler, S., Felder, B., Gasparoni, N., Imbusch, C. D., Hutter, B., Zipprich, G., Tauchmann, Y., Reinke, S., Wassilew, G., Hoffmann, U., Richter, A. S., Sieverling, L., Chang, H.-D., Syrbe, U., Kalus, U., Eils, J., Brors, B., Manke, T., Ruland, J., Lengauer, T., Rajewsky, N., Chen, W., Dong, J., Sawitzki, B., Chung, H.-R., Rosenstiel, P., Schulz, M. H., Schultze, J. L., Radbruch, A., Walter, J., Hamann, A. & Polansky, J. K. Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development.. 10.1016/j.immuni.2016.10.022.

Tedeschi, A., Dupraz, S., Laskowski, C. J., Xue, J., Ulas, T., Beyer, M., Schultze, J. L. & Bradke The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS.. 10.1016/j.neuron.2016.09.026. Epub 2016 Oct 6.

Schlitzer A, Schultze JL.Tissue?resident macrophages — how to humanize our knowledge. 10.1038/icb.2016.82. Epub 2016 Oct 18.

Schuette, V., Embgenbroich, M., Ulas, T., Welz, M., Schulte-Schrepping, J., Draffehn, A. M., Quast, T., Koch, K., Nehring, M., Konig, J., Zweynert, A., Harms, F. L., Steiner, N., Limmer, A., Forster, I., Berberich-Siebelt, F., Knolle, P. A., Wohlleber, D., Kolanus, W., Beyer, M., Schultze, J. L. & Burgdorf, S. Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4. 10.1073/pnas.1605885113. Epub 2016 Sep 6.

Mass, E., Ballesteros, I., Farlik, M., Halbritter, F., Gunther, P., Crozet, L., Jacome-Galarza, C. E., Handler, K., Klughammer, J., Kobayashi, Y., Gomez-Perdiguero, E., Schultze, J. L., Beyer, M., Bock, C. & Geissmann, F. Specification of tissue-resident macrophages during organogenesis. 10.1126/science.aaf4238. Epub 2016 Aug 4.

Schultze, J. L. Macrophage tolerance in the gut: It is in the epigenome! 10.1002/eji.201646545.

Szulzewsky, F., Arora, S., de Witte, L., Ulas, T., Markovic, D., Schultze, J. L., Holland, E. C., Synowitz, M., Wolf, S. A. & Kettenmann, H. Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples. Glia 64, 1416–1436 (2016).

Hagemeyer, N., Kierdorf, K., Frenzel, K., Xue, J., Ringelhan, M., Abdullah, Z., Godin, I., Wieghofer, P., Costa Jordao, M. J., Ulas, T., Yorgancioglu, G., Rosenbauer, F., Knolle, P. A., Heikenwalder, M., Schultze, J. L. & Prinz, M. Transcriptome?based profiling of yolk sac?derived macrophages reveals a role for Irf8 in macrophage maturation. EMBO J. 35, 1730–1744 (2016).

Carl-Philipp Hackstein, Lisa Mareike Assmus, Meike Welz, Sabine Klein, Timo Schwandt, Joachim Schultze, Irmgard Förster, Fabian Gondorf, Marc Beyer, Daniela Kroy, Christian Kurts, Jonel Trebicka, Wolfgang Kastenmüller, Percy A Knolle, Zeinab Abdullah Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. 10.1136/gutjnl-2015-311224. Epub 2016 Jul 18.

Beins, E., Ulas, T., Ternes, S., Neumann, H., Schultze, J. L., Zimmer, A. Characterization of inflammatory markers and transcriptome profiles of differentially activated embryonic stem cell?derived microglia. 10.1002/glia.22979. Epub 2016 Mar 9.

Brandstatter, O., Schanz, O., Vorac, J., Konig, J., Mori, T., Maruyama, T., Korkowski, M., Haarmann-Stemmann, T., von Smolinski, D., Schultze, J. L., Abel, J., Esser, C., Takeyama, H., Weighardt, H., Forster, I. Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor. 10.1038/srep26091.

Beyer, M., Abdullah, Z., Chemnitz, J. M., Maisel, D., Sander, J., Lehmann, C., Thabet, Y., Shinde, P. V, Schmidleithner, L., Kohne, M., Trebicka, J., Schierwagen, R., Hofmann, A., Popov, A., Lang, K. S., Oxenius, A., Buch, T., Kurts, C., Heikenwalder, M., Fatkenheuer, G., Lang, P. A., Hartmann, P., Knolle, P. A., Schultze, J. L. Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection. 10.1038/ni.3399. Epub 2016 Mar 7.

Sorg, U. R., Behnke, K., Degrandi, D., Reich, M., Keitel, V., Herebian, D., Deenen, R., Beyer, M., Schultze, J. L., Kohrer, K., Gabbert, H. E., Mayatepek, E., Haussinger, D., Pfeffer, K. Cooperative role of lymphotoxin ? receptor and tumor necrosis factor receptor p55 in murine liver regeneration. 10.1016/j.jhep.2015.12.006. Epub 2015 Dec 19.

Zimmer, S., Grebe, A., Bakke, S. S., Bode, N., Halvorsen, B., Ulas, T., Skjelland, M., De Nardo, D., Labzin, L. I., Kerksiek, A., Hempel, C., Heneka, M. T., Hawxhurst, V., Fitzgerald, M. L., Trebicka, J., Bjorkhem, I., Gustafsson, J.-A., Westerterp, M., Tall, A. R., Wright, S. D., Espevik, T., Schultze, J. L., Nickenig, G., Lutjohann, D., Latz, E. Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. 10.1126/scitranslmed.aad6100.

Shahbazi, E., Moradi, S., Nemati, S., Satarian, L., Basiri, M., Gourabi, H., Zare Mehrjardi, N., Gunther, P., Lampert, A., Handler, K., Hatay, F. F., Schmidt, D., Molcanyi, M., Hescheler, J., Schultze, J. L., Saric, T., Baharvand, H. Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor. 10.1016/j.stemcr.2016.02.013. Epub 2016 Mar 24.

Ginhoux, F., Schultze, J. L., Murray, P. J., Ochando, J., Biswas, S. K. New insights into the multidimensional concept of macrophage ontogeny, activation and function. 10.1038/ni.3324.

Deng, M., Bragelmann, J., Schultze, J. L., Perner, S. Web-TCGA: an online platform for integrated analysis of molecular cancer data sets. 10.1186/s12859-016-0917-9.

Schmidt, S. V, Krebs, W., Ulas, T., Xue, J., Bassler, K., Gunther, P., Hardt, A.-L., Schultze, H., Sander, J., Klee, K., Theis, H., Kraut, M., Beyer, M., Schultze, J. L. The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin. 10.1038/cr.2016.1. Epub 2016 Jan 5.

Schultze, J. L., Beyer, M. Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way. 10.1016/j.immuni.2015.12.019.

Schultze, J. L. Reprogramming of macrophages — new opportunities for therapeutic targeting. 10.1016/j.coph.2015.09.007. Epub 2015 Sep 29.

Aschenbrenner, A. C., Bassler, K., Brondolin, M., Bonaguro, L., Carrera, P., Klee, K., Ulas, T., Schultze, J. L. and Hoch, M. A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a. Sci. Rep. 7, 4056 (2017).

2015

Schultze, J. L. & Schmidt, S. V. Molecular features of macrophage activation. Semin. Immunol. 27, 416–423 (2015).

Milanez-Almeida, P., Ulas, T., Pasztoi, M., Glage, S., Schughart, K., Lutz, M. B., Schultze, J. L. & Huehn, J. CD11b+Ly6C++Ly6G- Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. Eur. J. Microbiol. Immunol. (Bp). 5, 246–255 (2015).

Vacchelli, E., Ma, Y., Baracco, E. E., Sistigu, A., Enot, D. P., Pietrocola, F., Yang, H., Adjemian, S., Chaba, K., Semeraro, M., Signore, M., De Ninno, A., Lucarini, V., Peschiaroli, F., Businaro, L., Gerardino, A., Manic, G., Ulas, T., Gunther, P., Schultze, J. L., Kepp, O., Stoll, G., Lefebvre, C., Mulot, C., Castoldi, F., Rusakiewicz, S., Ladoire, S., Apetoh, L., Bravo-San Pedro, J. M., Lucattelli, M., Delarasse, C., Boige, V., Ducreux, M., Delaloge, S., Borg, C., Andre, F., Schiavoni, G., Vitale, I., Laurent-Puig, P., Mattei, F., Zitvogel, L. & Kroemer, G. Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science 350, 972–978 (2015).

Labzin, L. I., Schmidt, S. V, Masters, S. L., Beyer, M., Krebs, W., Klee, K., Stahl, R., Lutjohann, D., Schultze, J. L., Latz, E. & De Nardo, D. ATF3 Is a Key Regulator of Macrophage IFN Responses. J. Immunol. 195, 4446–4455 (2015).

Bottcher, J. P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Hochst, B., Eickhoff, S., Rieckmann, J. C., Russo, C., Bauer, T., Flecken, T., Giesen, D., Engel, D., Jung, S., Busch, D. H., Protzer, U., Thimme, R., Mann, M., Kurts, C., Schultze, J. L., Kastenmuller, W. & Knolle, P. A. Functional classification of memory CD8+ T cells by CX3CR1 expression. Nat. Commun. 6, 8306 (2015).

Schultze, J. L., Schmieder, A. & Goerdt, S. Macrophage activation in human diseases. Semin. Immunol. 27, 249–256 (2015).

Schultze, J. L. Teaching 'big data' analysis to young immunologists. Nat. Immunol. 16, 902–905 (2015).

Schultze, J. L. Transcriptional programming of human macrophages: on the way to systems immunology. J. Mol. Med. (Berl). 93, 589–597 (2015).

Mitschka, S., Ulas, T., Goller, T., Schneider, K., Egert, A., Mertens, J., Brustle, O., Schorle, H., Beyer, M., Klee, K., Xue, J., Gunther, P., Bassler, K., Schultze, J. L. & Kolanus, W. Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71Sci. Rep. 5, 11126 (2015).

Sommer, D., Peters, A. E., Wirtz, T., Mai, M., Ackermann, J., Thabet, Y., Schmidt, J., Weighardt, H., Wunderlich, F. T., Degen, J., Schultze, J. L. & Beyer, M. Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleasesNature communications 6, 5927 (2015).

Fassl, S. K., Austermann, J., Papantonopoulou, O., Riemenschneider, M., Xue, J., Bertheloot, D., Freise, N., Spiekermann, C., Witten, A., Viemann, D., Kirschnek, S., Stoll, M., Latz, E., Schultze, J. L., Roth, J. & Vogl, T. Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8. J. Immunol. 194, 575–583 (2015).

Austermann, J., Friesenhagen, J., Fassl, S. K., Petersen, B., Ortkras, T., Burgmann, J., Barczyk-Kahlert, K., Faist, E., Zedler, S., Pirr, S., Rohde, C., Muller-Tidow, C., von Kockritz-Blickwede, M., von Kaisenberg, C. S., Flohe, S. B., Ulas, T., Schultze, J. L., Roth, J., Vogl, T. & Viemann, D. Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions. Cell Rep. 9, 2112–2123 (2014).

Krebs, W., Schmidt, S. V, Goren, A., De Nardo, D., Labzin, L., Bovier, A., Ulas, T., Theis, H., Kraut, M., Latz, E., Beyer, M. & Schultze, J. L. Optimization of transcription factor binding map accuracy utilizing knockout-mouse modelsNucleic Acids Res. 42, 13051–13060 (2014).

Sistigu, A., Yamazaki, T., Vacchelli, E., Chaba, K., Enot, D. P., Adam, J., Vitale, I., Goubar, A., Baracco, E. E., Remedios, C., Fend, L., Hannani, D., Aymeric, L., Ma, Y., Niso-Santano, M., Kepp, O., Schultze, J. L., Tuting, T., Belardelli, F., Bracci, L., La Sorsa, V., Ziccheddu, G., Sestili, P., Urbani, F., Delorenzi, M., Lacroix-Triki, M., Quidville, V., Conforti, R., Spano, J.-P., Pusztai, L., Poirier-Colame, V., Delaloge, S., Penault-Llorca, F., Ladoire, S., Arnould, L., Cyrta, J., Dessoliers, M.-C., Eggermont, A., Bianchi, M. E., Pittet, M., Engblom, C., Pfirschke, C., Preville, X., Uze, G., Schreiber, R. D., Chow, M. T., Smyth, M. J., Proietti, E., Andre, F., Kroemer, G. & Zitvogel, L. Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapyNat. Med. 20, 1301–1309 (2014).

Schmole, A.-C., Lundt, R., Ternes, S., Albayram, O., Ulas, T., Schultze, J. L., Bano, D., Nicotera, P., Alferink, J. & Zimmer, A. Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model. Neurobiol. Aging 36, 710–719 (2015).

2014

Bottcher, J. P., Schanz, O., Garbers, C., Zaremba, A., Hegenbarth, S., Kurts, C., Beyer, M., Schultze, J. L., Kastenmuller, W., Rose-John, S. & Knolle, P. A. IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell FunctionCell Rep. 8, 1318–1327 (2014).

Schmidt, S. V & Schultze, J. L. New insights into IDO biology in bacterial and viral infectionsFront. Immunol. 5, 384 (2014).

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., Locati, M., Mantovani, A., Martinez, F. O., Mege, J.-L., Mosser, D. M., Natoli, G., Saeij, J. P., Schultze, J. L., Shirey, K. A., Sica, A., Suttles, J., Udalova, I., van Ginderachter, J. A., Vogel, S. N. & Wynn, T. A. Macrophage activation and polarization: nomenclature and experimental guidelines.Immunity 41, 14–20 (2014).

Kummer, M. P., Hammerschmidt, T., Martinez, A., Terwel, D., Eichele, G., Witten, A., Figura, S., Stoll, M., Schwartz, S., Pape, H.-C., Schultze, J. L., Weinshenker, D., Heneka, M. T. & Urban, I. Ear2 Deletion Causes Early Memory and Learning Deficits in APP/PS1 MiceJ. Neurosci. 34, 8845–8854 (2014).

Schultze, J. L., Freeman, T., Hume, D. A. & Latz, E. A transcriptional perspective on human macrophage biologySemin. Immunol. 27, 44–50 (2015).

Xue, J., Schmidt, S. V, Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., Ganesan, H., Nino-Castro, A., Mallmann, M. R., Labzin, L., Theis, H., Kraut, M., Beyer, M., Latz, E., Freeman, T. C., Ulas, T. & Schultze, J. L. Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation. Immunity 40, 274–288 (2014).

Globisch, T., Steiner, N., Fulle, L., Lukacs-Kornek, V., Degrandi, D., Dresing, P., Alferink, J., Lang, R., Pfeffer, K., Beyer, M., Weighardt, H., Kurts, C., Ulas, T., Schultze, J. L. & Forster, I. Cytokine‐dependent regulation of dendritic cell differentiation in the splenic microenvironmentEur. J. Immunol. 44, 500–510 (2014).

Sommer, D., Peters, A., Wirtz, T., Mai, M., Ackermann, J., Thabet, Y., Schmidt, J., Weighardt, H., Wunderlich, F. T., Degen, J., Schultze, J. L. & Beyer, M. Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleasesNat. Commun. 5, 3045 (2014).

Ma, Y., Mattarollo, S. R., Adjemian, S., Yang, H., Aymeric, L., Hannani, D., Portela Catani, J. P., Duret, H., Teng, M. W. L., Kepp, O., Wang, Y., Sistigu, A., Schultze, J. L., Stoll, G., Galluzzi, L., Zitvogel, L., Smyth, M. J. & Kroemer, G. CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon ChemotherapyCancer Res. 74, 436–445 (2014).

De Nardo, D., Labzin, L. I., Kono, H., Seki, R., Schmidt, S. V, Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F. A., Vogelhuber, J., Kraut, M., Ulas, T., Kerksiek, A., Krebs, W., Bode, N., Grebe, A., Fitzgerald, M. L., Hernandez, N. J., Williams, B. R. G., Knolle, P., Kneilling, M., Rocken, M., Lutjohann, D., Wright, S. D., Schultze, J. L. & Latz, E. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3Nat. Immunol. 15, 152–160 (2014).

2013

Lubkemeier, I., Andrie, R., Lickfett, L., Bosen, F., Stockigt, F., Dobrowolski, R., Draffehn, A. M., Fregeac, J., Schultze, J. L., Bukauskas, F. F., Schrickel, J. W. & Willecke, K. The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice.J. Mol. Cell. Cardiol. 65, 19–32 (2013).

Schermer, B., Bartels, V., Frommolt, P., Habermann, B., Braun, F., Schultze, J. L., Roodbergen, M., Hoeijmakers, J. H., Schumacher, B., Nurnberg, P., Dolle, M. E., Benzing, T., Muller, R.-U. & Kurschat, C. E. Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular aging. BMC Genomics 14, 559 (2013).

Nino-Castro, A., Abdullah, Z., Popov, A., Thabet, Y., Beyer, M., Knolle, P., Domann, E., Chakraborty, T., Schmidt, S. V & Schultze, J. L.The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes. Innate Immun. 20, 401–411 (2014).

Langhans, B., Kramer, B., Louis, M., Nischalke, H. D., Huneburg, R., Staratschek-Jox, A., Odenthal, M., Manekeller, S., Schepke, M., Kalff, J., Fischer, H.-P., Schultze, J. L. & Spengler, U. Intrahepatic IL-8 producing Foxp3(+)CD4(+) regulatory T cells and fibrogenesis in chronic hepatitis.C. J. Hepatol. 59, 229–235 (2013).

Beutner, C., Linnartz-Gerlach, B., Schmidt, S. V, Beyer, M., Mallmann, M. R., Staratschek-Jox, A., Schultze, J. L. & Neumann, H. Unique transcriptome signature of mouse microglia. Glia 61, 1429–1442 (2013).

Jux, B., Staratschek-Jox, A., Penninger, J. M., Schultze, J. L. & Kolanus, W. Vav1 regulates MHCII expression in murine resting and activated B cells. Int. Immunol. 25, 307–317 (2013).

Böttcher, J. P., Schanz, O., Wohlleber, D., Abdullah, Z., Debey-Pascher, S., Staratschek-Jox, A., Höchst, B., Hegenbarth, S., Grell, J., Limmer, A., Atreya, I., Neurath, M. F., Busch, D. H., Schmitt, E., van Endert, P., Kolanus, W., Kurts, C., Schultze, J. L., Diehl, L. & Knolle, P. A. Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity. Cell Rep. 3, 779–795 (2013).

2012

Roth, W., Kumar, V., Beer, H.-D., Richter, M., Wohlenberg, C., Reuter, U., Thiering, S., Staratschek-Jox, A., Hofmann, A., Kreusch, F., Schultze, J. L., Vogl, T., Roth, J., Reichelt, J., Hausser, I. & Magin, T. M. Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. . J. Cell Sci. 125, 5269 LP-5279 (2012).

Herzfeld, T., Nolte, D., Grznarova, M., Hofmann, A., Schultze, J. L. & Müller, U. X-linked dystonia parkinsonism syndrome (XDP, lubag): disease-specific sequence change DSC3 in TAF1/DYT3 affects genes in vesicular transport and dopamine metabolism. . Hum. Mol. Genet. 22, 941–951 (2013).

Beyer, M. Interleukin-2 treatment of tumor patients can expand regulatory T cells. . Oncoimmunology 1, 1181–1182 (2012).

Beyer, M., Mallmann, M. R., Xue, J., Staratschek-Jox, A., Vorholt, D., Krebs, W., Sommer, D., Sander, J., Mertens, C., Nino-Castro, A., Schmidt, S. V & Schultze, J. L.High-Resolution Transcriptome of Human Macrophages. . PLoS One 7, e45466 (2012).

Schmidt, S. V., Nino-Castro, A. C. & Schultze, J. L.Regulatory dendritic cells: There is more than just immune activation. Front. Immunol. 3, 1–17 (2012).