Lab Head: Prof. Dr. Dr. h. c. Michael Hoch
Head of the Molecular Developmental Biology lab
currently represented by
Priv. Doz. Dr. Reinhard Bauer
Room No. I-108
phone: 0 2 28 / 73 - 6 27 44
r.bauer@uni-bonn.de
Education
1983–1989 | Study of Biology (Diplom), University of Heidelberg |
1987 | Research Student with Prof. Moshe Yaniv, Institut Pasteur, Paris |
1989-1992 | Doctorate in Biology (Dr. rer. nat.) Ludwig-Maximilians-University, Munich, Mentor Prof. Herbert Jäckle |
1992-1994 | Postdoctoral fellow with Prof. Herbert Jäckle, Department of Molecular Developmental Biology, Max-Planck-Institute for Biophysical Chemistry, Göttingen |
1994-1998 | Independent Group leader, Department of Molecular Developmental Biology, Max-Planck-Institute for Biophysical Chemistry, Göttingen |
1996 | Habilitation and Venia legendi in Developmental Genetics and Cell Biology, Technical University of Braunschweig, Mentor Prof. Hans-Henning Arnold |
1999-present | Chair of Molecular Developmental Biology, University of Bonn |
2000-2002 | Director, Institute of Animal Physiology, University of Bonn |
2000-2006 | Foundation and Coordination of the German Undergraduate Study Program of excellence in Molecular Biomedicine (Diplom), Division Molecular Biomedicine, Faculty for Mathematics & Natural Sciences, University of Bonn |
2006-2015 | Managing Director, Life & Medical Sciences (LIMES) Institute Bonn |
since May 2015 | Rector of the University of Bonn |
Honors and Awards
1986-1989 | Student Fellowship of the German National Merit Foundation (Studienstiftung des dt. Volkes) |
1989-1992 | PhD Fellowship of the Boehringer Ingelheim Fonds (foundation for the promotion of basic research in biomedicine, Mainz) |
1996 | Gerhard Hess Young Investigator Award (German Research Foundation) |
2000-2007 | Member of the reviewer panel for the award of Post Graduate Fellowships of the DAAD (German Academic Exchange Service) |
2001-2004 | Speaker of the Research Unit FOR 425 |
2002-2004 | Chairman of the Bonner Forum Biomedizin (BFB) |
2002-2004 | Member of the Post Graduate Program GRK 721 "Evolution und Biodiversität in Raum und Zeit" (Speaker: K.-P. Sauer, Bonn) |
2002-2011 | Member of the DFG Post Graduate Program GRK 804 (Speaker: M. Famulok, Bonn) |
2003-2004 | Head of the Biology Division of the Faculty for Mathematics & Natural Sciences, University of Bonn |
2006-2009 | Founding Head of the Molecular Biomedicine Division (Fachgruppe) of the Faculty for Mathematics & Natural Sciences, University of Bonn |
2010 | Visiting Research Professor, Waseda University, Tokyo |
2005-2016 | Speaker of the Collaborative Research Center SFB 645 (DFG) |
Since 2006 | Member of the Steering Committee of the Collaborative Research Center SFB 704 (DFG) |
2009-2012 | Member of the Steering Committee of the Collaborative Research Center SFB 832 (DFG) |
2009-2015 | Member of the Minerva Fellowship Committee for the promotion of German/Israeli research, Max-Planck-Society, Munich |
2012-2015 | Member of the Steering Committee of the Bonn Excellence Cluster ImmunoSensation (DFG) |
2013-2015 | Member of the PhD Fellowship Selection Committee of the German National Merit Foundation (Studienstiftung des dt. Volkes) |
2013-2015 | Member of the Board of Trustees (“Stiftungsrat) of the Bonn University Foundation (Bonner Universitätsstiftung) |
2014-2015 | Member of the Board of the Universitätsclub of the University of Bonn |
2014-2015 | Member of the Senate of the University of Bonn |
2017 | Honorary Doctorate of Waseda University, Tokyo |
2019 | University Manager of the Year 2019 |
2020 | Entry in the Golden Book of the city of Bonn |
2020 | Rector of the Year 2020 |
Research Expertise
Our aim is to identify new key regulators and genetic networks which control metabolism and cell and organ physiology. In particular, we elucidate the metabolism – innate immunity – gut microbiome axis, we investigate cellular (sphingo)lipid metabolism and body fat regulation, we study peroxisome and lysosome biogenesis and metabolic disorders (e.g. lipid storage diseases or neurodegeneration), and we analyse new regulators of cell-to-cell communication and tissue physiology. We use the fruit fly Drosophila, the mouse and zebra fish as genetic model organisms for our studies.
Selected Publications
Mass E, Wachten D, Aschenbrenner AC, Voelzmann A, Hoch M. 2014. Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling. Developmental Cell 28, 711-726. DOI: 10.1016/j.devcel.2014.02.012.
Becker T, Loch G, Beyer M, Zinke I, Aschenbrenner AC, Carrera P, Inhester T, Schultze JL, Hoch M. 2010. FOXO-dependent regulation of innate immune homeostasis. Nature 463: 369-73
Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, Eckardt F, Sandhoff K, Hoch M. 2009. Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J 28: 3706-16
Behr M, Wingen C, Wolf C, Schuh R, Hoch M. 2007. Wurst is essential for airway clearance and respiratory-tube size control. Nat Cell Biol 9: 847-53
Fuss B, Becker T, Zinke I, Hoch M. 2006. The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 444: 945-8