Willkommen bei der Arbeitsgruppe Kiermaier!

The group focuses on the contribution of centrosomes during innate and adaptive immune responses. While centrosomes have been extensively studied during cell division and in the context of tumorigenesis, recent data in macrophages suggest a novel role during innate immunity (Vertii et al., Immunity, 2016). 
Dendritic cells represent the most potent antigen presenting cells of the innate immune system. They are key mediators for the induction of protective immunity as well as maintenance of self-tolerance (Förster et al., Nat Rev Immunol, 2008). As such, dendritic cells represent an outstanding population of cells, which mediate three fundamentally important tasks: antigen capture and presentation, migration and T cell activation. The group studies how centrosomes impact immune cell effector functions such as antigen presentation and migration and their behavior upon lymphocyte cell-cell interactions. We will particularly focus on the phenomenon of centrosome amplification, which is primarily studied in the context of tumorigenesis underscoring the importance of investigating a potential physiological relevance of excess centrosomes in somatic cells.

Publications:

1. Kiermaier E*§, Moussion C*, Veldkamp CT, Gerardy-Schahn R, de Vries I, Williams LG, Chaffee GR, Phillips AJ, Freiberger F, Imre R, Taleski D, Payne RJ, Braun A, Förster R, Mechtler K, Mühlenhoff M, Volkman BF, Sixt M§ (2015) Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science 351(6269):186-190. 

2. Veldkamp CT, Kiermaier E, Gabel-Eissens SJ, Gillitzer ML, Lippner DR, DiSilvio FA, Mueller CJ, Wantuch PL, Chaffee GR, Famiglietti MW, Zgoba DM, Bailey AA, Bah Y, Engebretson SJ, Graupner DR, Lackner ER, LaRosa VD, Medeiros T, Olson ML, Phillips AJ, Pyles H, Richard AM, Schoeller SJ, Touzeau B, Williams LG, Sixt M, Peterson FC. (2015) Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites. Biochemistry 14;54(27):4163-6.

3. Molatore S, Kiermaier E, Jung CB, Lee M, Pulz E, Höfler H, Atkinson MJ, Pellegata NS. (2010) Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors. Molecular Cancer 9:116.

4. Kiermaier E, Woehrer S, Peng Y, Mechtler K, Westermann S (2009) A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast. Nature Cell Biology 11(9):1109-15.


*equally contributing authors. §corresponding authors.