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WGGC: DZNE and the LIMES Institute

Post-doctoral position in Bioinformatics

The WGGC (West German Genome Center) facilitate centralized NGS (Next-generation-sequencing) services while combining existing centralized NGS- and bioinformatics expertise at selected sites like DZNE (German Center for Neurodegenerative Diseases within the Helmholtz Association) and University of Bonn (LIMES - Life and Medical Sciences Institute). PRECISE (Platform for Single Cell Genomics and Epigenomics), which is part of the DZNE and University of Bonn, is one of the selected sites within the WGGC. PRECISE uses high throughput technologies such as liquid handling robots and NGS, to answer basic and translational scientific questions in the area of neurodegenerative diseases and immunology together with local, national and international collaboration partners. PRECISE, together with the other sites, will commit the newly acquired NGS and bioinformatics capacity as service to the community. WGGC partners will also serve the scientific community through the provision of consultation, collaboration, and/or data analysis. The successful candidate will be part of the WGGC at PRECISE and responsible for automation and optimization of the NGS data analysis workflows in a HPC (High-performance computing) environment.

Our requirements are

  • Strong background in computational biology, bioinformatics, biomathematics, biostatistics is of advantage.
  • Knowledge and experience in the analysis of RNA-Seq, ChIP-Seq and ATAC-Seq data.
  • Experience in object-oriented software development, ideally with C++ and python is of advantage.
  • A collaborative attitude.
  • Ability to work independently as well as in a team.
  • Very good communications and writing skills in English.
  • Strong background in biology, preferable immunology.
  • Experience in High-performance computing.
  • Computer programming skills.
  • PhD degree or equivalent in bioinformatics or related fields.
  • Enthusiasm to work in a thriving academic research environment.
  • An interest to work in an international environment.

What we have to offer

  • Participation in a challenging project within WGGC
  • State of the art technologies to tackle important scientific and medical questions also in collaboration with industry partners
  • A lot of expertise with the WGGC and the associated partners
  • A thriving interdisciplinary research environment at PRECISE
  • Fully established bioinformatics department

 

The position is available for an initial period of two years with possible extension and the salary is paid according to German TV-L (E 13 100%).

The DZNE and the University of Bonn are equal opportunities employers.

Applications (in English) should include a CV, a brief statement of research experiences and interests, a list of publications and the addresses of two referees, and should be submitted as a single pdf file to Dr. Thomas Ulas (t( dot )ulas( at)uni-bonn( dot )de) with the application code “WGGC” by 01st of December 2021.


The Rheinische Friedrich-Wilhelms-Universität Bonn is an international research university with a broad spectrum of disciplines. 200 years of history, around 38,000 students, more than 6,000 employees and an excellent reputation at home and abroad: The University of Bonn is one of the most important universities in Germany and has been awarded the title of Excellence University.
The bioinformatics unit of the Platform for Single Cell Genomics and Epigenomics (PRECISE) at the Department of Genomics & Immunoregulation at the Life & Medical Sciences (LIMES) Institute of the University of Bonn are looking for an

PhD candidate in computational biology/bioinformatics

starting between January-March 2022 for three years in the field of bulk and single-cell transcriptome analysis.

The LIMES Institute is part of the Faculty of Mathematical and Natural Sciences at the University of Bonn. The Institute has been established to foster molecular research spanning from immunology to metabolism using a broad spectrum of cutting-edge technologies including state-of –the-art genomic technologies. In this regard, the Department for Genomics and Immunoregulation at the LIMES-Institute together with PRECISE at the DZNE Bonn are now seeking for scientists in the field of bioinformatics, computational biology and systems biology with focus in transcriptomics and data integration with a strong focus in neonatal immunology. The successful candidate will be part of a team analyzing immunological multiomics data and improving/developing computational approaches using state of the art tools and IT infrastructure in Bonn.

Our requirements are

  • Strong background in computational biology, bioinformatics, biomathematics, biostatistics
  • Computer programming skills.
  • Experience in the analysis of single-cell RNA-Seq and bulk RNA-Seq.
  • Background in biology, preferable immunology.
  • Master’s degree or equivalent.
  • Very good communications and writing skills in English.
  • Enthusiasm to work in a thriving academic research environment.
  • An interest to work in an international environment.
  • A collaborative attitude.
  • Ability to work independently as well as in a team.

What we have to offer

  • A challenging and versatile research project focusing on neonatal immunology.
  • State of the art technologies to tackle important scientific and medical questions.
  • A thriving interdisciplinary research environment at PRECISE and the Limes Institute.
  • A fully established bioinformatics department.

Salary is paid according to German TV-L (E 13 65%).

The University of Bonn is an equal opportunities employer.

Complete applications in English should include a motivation letter (max. 1 page), a CV, a brief statement of research experiences and interests, list of publications (if applicable) and addresses of two referees and should be submitted in one pdf file to Dr. Thomas Ulas (t( dot )ulas( at)uni-bonn( dot )de) with the application code “PhD-bioinformatics” by 17th of December 2021.

 


PostDoc PRECISE (f/m/x)

The joint Platform for Single Cell Genomics and Epigenomics (PRECISE) at the DZNE and the Rheinische Friedrich-Wilhelm-Universität Bonn is looking for a full-time (39 hours per week) scientist working at PRECISE in the areas of next-generation sequencing, single-cell OMICS, and to support the technical and scientific directors. The position is available for an initial period of three years with possible extension. The employment is intended to start in January 2022 or upon agreement.

The main research interest of PRECISE lies in the establishment, application and improvement of single-cell OMICs methods in the areas of neurodegeneration and immunology.

For more general information, please also visit the website of PRECISE

https://www.dzne.de/forschung/precise/


Your tasks

The successful candidate will work together with the PRECISE team and use the most advanced genomic methods (SMART-Seq2, SeqWell, BD Rhapsody, 10X Genomics, RNA-Seq, ChIP-Seq, ATAC-Seq) within the framework of our cooperative projects and your own research work. Scientific topics covered include basic immunology & neuroscience, human population studies and clinical samples from e.g. individuals suffering from neurodegenerative disease.

The candidate is encouraged to further develop and implement methods in the areas of next-generation sequencing, single-cell OMICS, transcriptomics and genomics/epigenomics using material from animal models as well as human patients.

The successful candidate will be involved in the establishment and improvement of single-cell RNA-Seq methods, in automation and process optimization and in the organization of the project workflow.

Requirements

  • For this position, we are seeking a highly motivated, team-oriented PostDoc, with knowledge in the field of molecular biology, genomics, transcriptomics or epigenomics, next generation sequencing, single-cell OMICs or process automation
  • The applicant should hold a PhD or MD/PhD degree in molecular biomedicine, biology, immunology, neurobiology, biotechnology or similar topics
  • Prior experience in single-cell OMICs, transcriptomics, molecular biology or high throughput sequencing techniques is desired
  • Computer, statistical, and programming skills are advantageous.
  • Advanced communication skills and very profound German or English language skills are required
  • We expect a highly motivated and independently working candidate, and willingness to work in a diverse team with international scientists who is interested to participate in supervision of undergraduate and graduate students

 We offer

  • A responsible, versatile and team-oriented job, which also gives you the opportunity to act on your own responsibility within the PRECISE framework, in one of the most modern scientific institutes in Germany
  • Excellent scientific infrastructure and state-of-the-art methodologies
  • An international environment characterized by a strong focus on science and research
  • A high potential for individual development of our employees (including targeted personnel development)
  • A full-time position, initially limited to three years
  • Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund)

Please submit your application using the online system, consisting of your CV (incl. two references) and a brief cover letter (max. 1 page) stating your motivation for and prior experience relating to this project.

If you have further questions, please contact joachim.schultze@dzne.de or marc.beyer@dzne.de. Interviews will take place by video conference, with a possible on-site visit to Bonn. The position is available immediately and applications will be considered until the position is filled (with a possible starting date being 1st January 2022).


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