Original Publikationen

Hitschler, L. and Lang, T. (2022). The transmembrane domain of the amyloid precursor protein is required for amyloidogenic processing by a-secretase ADAM10. J. Biol. Chem. 298, 101911

Reppert, N. and Lang, T. (2022). A conserved sequence in the small intracellular loop of tetraspanins forms an M-shaped inter-helix turn. Sci. Rep. 12, 4494

Mertins, J., Finke, J., Sies, R., Rink, K.M., Hasenauer, J., and Lang, T. (2021). The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE-SNARE interactions. Elife 10, e69236

Finke, J., Hitschler, L., Boller, K., Florin, L., and Lang, T. (2020). HPV caught in the tetraspanin web? Med. Microbiol. Immunol. 209, 447-459

Finke, J., Mikuličić, S., Loster, A.L., Gawlitza, A., Florin, L., and Lang, T. (2020). Anatomy of a viral entry platform differentially functionalized by integrins α3 and α6. Sci. Rep. 10, 5356

Hochheimer, N., Sies, R., Aschenbrenner, A.C., Schneider, D. and Lang T. (2019). Classes of non-conventional tetraspanins defined by alternative splicing. Sci. Rep. 9, 140

Mikuličić, S., Finke, J., Boukhallouk, F., Wüstenhagen, E., Sons, D., Homsi, Y., Reiss, K., Lang, T. and Florin, L. (2019). ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly. Elife 8, e44345

de Coninck D., Schmidt T.H., Schloetel J.G., Lang T. (2018). Packing Density of the Amyloid Precursor Protein in the Cell Membrane. Biophys J. 114,1128-1141

Merklinger E., Schloetel J.G., Weber P., Batoulis H., Holz S., Karnowski N., Finke J., Lang T. (2017). The packing density of a supramolecular membrane protein cluster is controlled by cytoplasmic interactions. Elife. 6. pii: e20705

Weber P., Batoulis H., Rink K.M., Dahlhoff S., Pinkwart K., Söllner T.H., Lang T. (2017). Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane. Elife. 6. pii: e19394

Niazy, N., Temme, S., Bocuk, D., Giesen, C., König, A., Temme, N., Ziegfeld, A., Gregers, T.F., Bakke, O., Lang, T., Eis-Hübinger, A.M. and Koch N. (2017). Misdirection of endosomal trafficking mediated by herpes simplex virus-encoded glycoprotein B. FASEB J. 31, 1650-1667

Homsi Y., Lang T. (2017). The specificity of homomeric clustering of CD81 is mediated by its δ-loop. FEBS Open Bio. 7(2):274-283

Schmidt, T.H., Homsi, Y., Lang, T. (2016). Oligomerization of the Tetraspanin CD81 via the Flexibility of Its δ-Loop. Biophys. J. 110(11), 2463-74

Batoulis, H., Schmidt, T.H., Weber, P., Schloetel, J.G., Kandt, C., Lang, T. (2016). Concentration Dependent Ion-Protein Interaction Patterns Underlying Protein Oligomerization Behaviours. Sci. Rep. 6, 24131

Merklinger, E., Schloetel, J.G., Spitta, L., Thiele, C., Lang, T. (2016). No Evidence for Spontaneous Lipid Transfer at ER-PM Membrane Contact Sites. J. Membr. Biol. 249(1-2), 41-56

Zehner, M., Marschall, A.L., Bos, E., Schloetel, J.G., Kreer, C., Fehrenschild, D., Limmer, A., Ossendorp, F., Lang, T., Koster, A.J., Dübel, S., Burgdorf, S. (2015). The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells. Immunity. 42(5), 850-863

Homsi, Y., Schloetel, J.G., Scheffer, K.D., Schmidt, T.H., Destainville, N., Florin, L., Lang, T. (2014). The extracellular δ-domain is essential for the formation of CD81 tetraspanin webs. Biophys. J. 107, 100-113

Saka, S.K., Honigmann, A., Eggeling, C., Hell, S.W., Lang, T., Rizzoli, S.O., (2014) Multi-protein assemblies underlie the mesoscale organization of the plasma membrane. Nat. Commun. 5(4509)

Lauria, I., van Üüm, J., Mjumjunov-Crncevic, E., Walrafen, D., Spitta, L., Thiele, C. and Lang, T. (2013). GLTP mediated non-vesicular GM1 transport between native membranes. PLoS One. 8(3)

Niwa, D., Fujie, T., Lang, T., Goda, N. and Takeoka, S. (2012). Heterofunctional nanosheet controlling cell adhesion properties by collagen coating. J. Biomater. Appl. 27(2), 131-141

Schreiber, A., Fischer, S. and Lang, T. (2012). The Amyloid Precursor Protein Forms Plasmalemmal Clusters via Its Pathogenic Amyloid-β-Domain. Biophys. J. 102, 1411-1417

Quast, T., Eppler, F., Semmling, V., Schild, C., Homsi, Y., Levy, S., Lang, T., Kurts, C. and Kolanus, W. (2011). CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration. Blood 118, 1818-1827

Okamura, Y., Schmidt, R., Raschke, I., Hintze, M., Takeoka, S., Egner, A. and Lang T. (2011). A Few Immobilized Thrombins are Sufficient for Platelet Spreading. Biophys. J. 100, 1855-1863

Aquino, D., Schönle, A., Geisler, C., v. Middendorff, C., Wurm, C.A., Okamura, Y., Lang, T., Hell, S.W. and Egner, A. (2011). Two color nanoscopy of three-dimensional volumes by 4Pi detection of stochastically switched fluorophores. Nat. Methods 8, 353-359

Zilly, F.E., Halemani, N.D., Walrafen, D., Spitta, S., Schreiber, A., Jahn, R. and Lang, T. (2011). Ca2+ Induces Clustering of Membrane Proteins in the Plasma Membrane Via Electrostatic Interactions. EMBO J. 30, 1209-1220

Bill, A., Schmitz, A., Albertoni, B., Song, J.N., Heukamp, L.C., Walrafen, D., Thorwirth, F., Verveer, P.J., Zimmer, S., Meffert, L., Schreiber, A., Chatterjee S., Thomas, R.K., Ullrich, R.T., Lang, T., Famulok, M. (2010). Cytohesins are cytoplasmic ErbB Receptor Activators. Cell 143, 201-211

Halemani, N.D., Bethani, I. Rizzoli, S.O. and Lang, T. (2010). Structure and dynamics of a two-helix-SNARE-complex in live cells. Traffic11, 394-404

Bar-On, D., Gutman, M., Mezer, A., Ashery, U., Lang, T. and Nachliel, E. (2009). Evaluation of the heterogeneous reactivity of the syntaxin molecules on the inner leaflet of the plasma membrane. J. Neurosci. 29, 12292-12301

Nawaz, S. Kippert, A., Saab, A.S., Werner, H.B., Lang, T., Nave, K.A. and Simons, M. (2009). Phosphatidynylinositol (4,5) biphosphate dependent interaction of MBP with the plasma membrane in oligodendroglial cells ans its rapid perturbation by elevated calcium. J. Neurosci. 29, 4794-4807

Bar-On, D., Winter, U., Nachliel, E., Gutman, M., Fasshauer, F., Lang, T. and Ashery, U. (2008). Imaging the assembly and disassembly kinetics of cis-SNARE complexes on native plasma membranes. FEBS Lett. 582, 3563-3568

Barszczewski, M., Chua, J.J., Stein, A., Winter, U., Heintzmann, R., Zilly, F.E., Fasshauer, D., Lang, T. and Jahn, R. (2008). A Novel Site of Action for {alpha}-SNAP in the SNARE Conformational Cycle Controlling Membrane Fusion. Mol. Biol. Cell 19, 776-784

Bethani, I., Lang, T., Geumann, U., Sieber, J.J., Jahn, R. and Rizzoli, S.O. (2007). The Specificity of SNARE Pairing in Biological Membranes is Mediated by both Proof-Reading and Spatial Segregation. EMBO J. 26, 3981-3992

Sieber, J.J., Willig, K.I., Kutzner, C., Gerding-Reimers, C., Harke, B., Donnert, G., Rammner, B., Eggeling, C., Hell, S.W., Grubmüller, H. and Lang, T. (2007). Anatomy and dynamics of a supramolecular membrane protein cluster. Science 317, 1072-1076

Renner, U., Glebov, K., Lang, T., Papusheva, E., Balakrishnan, S., Keller, B., Richter, D.W., Jahn, R. and Ponimaskin, E. (2007). Localization of the Mouse 5-Hydroxytryptamine1A Receptor in Lipid Microdomains Depends on its Palmitoylation and is Involved in Receptor-Mediated Signaling. Mol. Pharmacol. 72, 503-513

Borroni, V., Baier, C.J., Lang, T., Bonini, I., White, M.M., Garbus, I. and Barrantes, F.J. (2007). Cholesterol depletion activates rapid internalization of submicron-sized acetylcholine receptor domains at the cell membrane. Mol. Membr. Biol. 24, 1-15

Zilly, F.E., Sørensen, J.B., Jahn, R. and Lang, T. (2006). Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes. PLoS Biol. 4, 1789-1797 (e330)

Brandhorst, D., Zwilling, D., Rizzoli, S.O., Lippert, U., Lang, T. and Jahn, R. (2006). Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity. Proc. Natl. Acad. Sci. USA 103, 2701-2706

Sieber, J.J., Willig, K.I., Heintzmann, R., Hell, S.W. and Lang, T. (2006). The SNARE-motif is essential for the formation of syntaxin clusters in the plasma membrane. Biophys. J. 90, 2843-2851

Nagy, G., Milosevic, I., Fasshauer, D., Müller, E.M., De Groot, B.L., Lang, T., Wilson, M.C. and Sørensen, J.B. (2005). Alternative splicing of SNAP-25 regulates secretion through non-conservative substitutions in the SNARE domain. Mol. Biol. Cell. 16, 5675-5685

Schütz, D., Zilly, F., Lang, T., Jahn, R. and Bruns, D. (2005). A dual function for munc-18 in exocytosis. Eur. J. Neurosci. 21, 2419-2432

Milosevic, I., Sørensen, J.B., Lang, T., Krauss, M., Nagy, G., Haucke, V., Jahn, R. and Neher, E. (2005). Plasmalemmal PI(4,5)P2 level regulates the releasable vesicle pool size in chromaffin cells. J. Neurosci. 25, 2557-2565

Hatsuzawa, K., Lang, T., Bruns, D., Fasshauer, D. and Jahn, R. (2003). The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis. J. Biol. Chem. 278, 31159-31166

Holroyd, P., Lang, T., Wenzel, D., De Camilli, P. and Jahn, R. (2002). Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells. Proc. Natl. Acad. Sci. U S A 99, 16806-16811

Lang, T., Margittai, M., Hölzler, H. and Jahn, R. (2002). SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs. J. Cell Biol. 158, 751-760

Lang, T., Bruns, D., Wenzel, D., Riedel, D., Holroyd, P., Thiele, C. and Jahn, R. (2001). SNAREs are Concentrated in Cholesterol-Dependent Clusters that Define Docking and Fusion Sites for Exocytosis. EMBO J. 20, 2202-2213

Lang, T., Wacker, I., Wunderlich, I., Rohrbach, A., Giese, G., Soldati, T. and Almers, W. (2000). Role of Actin Cortex in the Subplasmalemmal Transport of Secretory Granules in PC-12 Cells. Biophys. J. 78, 2863-2877

Avery, J., Ellis, D.J., Lang, T., Holroyd, P., Riedel, D., Henderson, R.M., Edwardson, J.M. and Jahn, R. (2000). A Cell-free System for Regulated Exocytosis in PC12 Cells. J. Cell Biol. 148, 317-324

Lang, T. and Kessler, D. (1999). Evidence for Cysteine Persulfide as Reaction Product of L-Cyst(e)ine C-S-Lyase (C-DES) from Synechocystis. Analyses Using Cystine Analogues and Recombinant C-des. J. Biol. Chem. 274, 189-195

Lang, T., Wacker, I., Steyer, S., Kaether, C., Wunderlich, I., Soldati, T., Gerdes, H.-H. and Almers., W. (1997). Ca2+-Triggered Peptide Secretion in Single Cells Imaged with Green Fluorescent Protein and Evanescent Wave Microscopy. Neuron 18, 857-863


Lang, T. and Hochheimer, N. (2020). Tetraspanins. Curr. Biol. 30, R204-R206

Florin, L. and Lang, T. (2018). Tetraspanin Assemblies in Virus Infection. Front Immunol. 9, 1140

Fast, L.A., Lieber, D., Lang, T., Florin L. (2017). Tetraspanins in infections by human cytomegalo- and papillomaviruses. Biochem Soc Trans. 45, 489-497

Destainville, N., Schmidt, T.H., Lang, T. (2016). Where Biology Meets Physics--A Converging View on Membrane Microdomain Dynamics. Curr. Top. Membr. 77, 27-65

Lang, T. and Rizzoli, S. (2010). Membrane protein clusters at nanoscale resolution: more than pretty pictures. Physiology (Bethesda) 25, 116-124

Lang, T., Halemani, N.D. and Rammner, B. (2008). Interplay between lipids and the proteinaceous membrane fusion machinery. Prog. Lipid Res. 47, 461-469

Lang, T. (2007). SNARE Proteins and Membrane Rafts. J. Physiol. 585, 693-698

Lang, T. (2003) Imaging SNAREs at work in “unroofed cells” – approaches that may be of general interest for functional studies on membrane proteins. Biochem. Soc. Trans. 31, 861-864

Jahn, R., Lang, T. and Südhof, T. (2003). Membrane fusion. Cell 112, 519-533

Buchkapitel & Sonstiges

Embgenbroich., M., Mertins, J., Lang, T. and Burgdorf, S. (2019). Monitoring Intracellular Routing of Internalized Antigens by Immunofluorescence Microscopy. Methods Mol. Biol. 1988, 249-257 (book chapter)

van den Bogaart, G., Lang, T. and Jahn, R. (2013). Microdomains of SNARE proteins in the plasma membrane. Curr. Top. Membr., Elsevier

Lang, T. and Jahn, R. (2009). Botulinum and tetanus toxins. Encyclopedia of Neuroscience (Ed. L. Squire), Elsevier Science

Lang, T. (2008). Imaging Ca2+-triggered exocytosis of single secretory granules on plasma membrane lawns from neuroendocrine cells. Methods Mol. Biol. 440, 51-59

Lang, T. and Jahn, R. (2008). Core proteins of the secretory machinery. Handb Exp Pharmacol. 184, 107-127

Jahn, R. and Lang, T. (2004). Exocytosis. Encyclopedic Reference of Molecular Pharmacology (Eds. Stefan Offermanns and Walter Rosenthal), Springer Verlag

Lang, T. and Jahn, R. (2002). Fusion of vacuoles – where are the membranes, and where are the holes? (Preview) Dev. Cell 2, 257-25